Epileptiform seizures with maprotiline hydrochloride.

Epileptiform seizures with maprotiline hydrochloride.

Two cases are described who developed epileptic seizures whilst taking maprotiline hydrochloride in therapeutic dosage. In both cases the electroencephalogram was normal and the fits stopped on withdrawal of the drug.

Periodic lateralized epileptiform discharges: association with seizures

The clinical features and EEGs of 45 consecutive patients (40 adults and 5 children) who had periodic lateralized epileptiform discharges (PLEDs) were reviewed to determine the relationship between seizures and PLEDs. Focal encephalitis and ischemic stroke were the most frequent underlying processes for adult patients. All of the children, but only six of the adults, had long-lasting cerebral d...

On Epilepsy and Epileptiform Seizures : Their Causes, Pathology, and Treatment

Potassium accumulation in interstitial space during epileptiform seizures.

The K4a surface efflux from the cat neocortex and rat hippocampus was studied after preloading with K”a from the surface. This K4s efflux increases from two to nine times during or after all electrically or Metrazol-induced seizures and “spontaneous” seizures. The K4s influx does not change during a seizure, so this increased efflux is not due to change in the diffusion constant or water flow f...

Interictal epileptiform discharges do not change before seizures during sleep.

PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...